Use of Coenzyme Q10 in Oreochromis niloticus Culture, Antioxidant Activity, and Health Indicators: A Systematic Review with Meta-Analysis
aquaculture, ubiquinol, oxidative stress, immunity
Aquaculture has been going through significant transformations, and growing worldwide year by year, with animal protein sources in the same proportion of their growth, the environmental impacts of these crops have been the subject of great concern and studies. Coenzyme Q10 supplementation in different animal models has shown its great capacity as an antioxidant and has improved the health and immunity of these animals. The animal challenges in an aquatic environment are numerous, and different situations in productive management, lead to stressful conditions, which can impact the animal health as well as the productive success of cultures. This research aimed to investigate whether Coenzyme Q10 supplementation in Oreochromis niloticus improves gains for this animal's health. A systematic review was carried out with meta-analyses of previously published data. The strategic question was established using the PICO acronym for systematic review, two reviewers participated in data collection, and independent analyzes were performed using previously defined eligibility criteria. Studies included in the systematic review underwent data extraction and assessment of methodological quality and risk of bias. Evidence analysis revealed that using coenzyme Q10 improves the antioxidant activity of O. niloticus and hematological indicators when exposed to challenging conditions. The meta-analysis showed high homogeneity, demonstrating the need for further studies to strengthen the evidence.