Banca de DEFESA: MANOELLA PEREIRA DE SOUZA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MANOELLA PEREIRA DE SOUZA
DATE: 21/12/2023
TIME: 14:00
LOCAL: CPF - Sede (sala virtual)
TITLE:

The treatment of tegumentary leishmaniasis in children: a systematic review.

KEY WORDS:

Medication; Leishmaniasis; Pediatrics.

PAGES: 52
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Introduction: Tegumentary Leishmaniasis (TL) is an infectious, non-contagious disease that causes ulcers on the skin and mucous membranes, caused by protozoa of the genus Leishmania. In Brazil, there are seven species of leishmania involved in the occurrence of cases of this disease. Therefore, therapeutic treatment is challenging, especially for pregnant women, breastfeeding women, children, the elderly, people with chronic illnesses and individuals with a depressed immune system. With a medicinal arsenal consisting mainly of parenteral drugs, and with frequent side effects, the search for therapeutic guidance for this disease, which occurs predominantly in rural areas, is faced with precarious health structures, especially for the pediatric population. Objective: To investigate the main treatments used for Cutaneous Leishmaniasis in children andtheir implications. Methodology: Concerns a systematic review of the literature on medications used to treat cutaneous leishmaniasis in children. The selection of articles analyzed followed in the form of a flow, according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), with the Acronym PICOS defining the eligibility criteria for children, available treatments, supportive care, relapses and healing. The electronic search took place in the following databases: LILACS, SCIELO and PUBMED, using the Boolean operator AND with the combination of the following descriptors: “cutaneous leishmaniasis ", "treatment" and “children”. Studies that were not focused on the treatment of leishmaniasis were excluded, such as those that report responses and pathways of action of the immune system or epidemiological distribution, and only articles on treatments used in LT in pediatric patients that had been published in the last five years were selected. Results: The systematic review highlighted five main treatments for leishmaniasis in pediatric patients, namely: pentavalent antimonials, amphotericins, pentamidine, miltefosine and azoles. The results highlight a great concern about the toxicity of the drugs adopted and their side effects, especially in the treatment of children, with pentavalent antimonies as the main promoters of adverse reactions and toxicity. Furthermore, some of the articles analyzed point out the low cure rate of pentamidine and, in certain species of Leishmania, the ineffectiveness of azoles. Therefore, amphotericins (mainly liposomal version B) and miltefosine showed the best results in relation to their performance in the treatment of leishmaniasis in children. However, the need for more research and larger samples is highlighted to assess the viability and applicability of these medications.

COMMITTEE MEMBERS:
Interno - 1822195 - DELIO JOSE MORA AMADOR JUNIOR
Interno - 3067563 - EZEQUIEL BATISTA DO NASCIMENTO
Presidente - 1148017 - LUIZ HENRIQUE SANTOS GUIMARAES