Banca de DEFESA: HERMINIO ASEVEDO NETO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : HERMINIO ASEVEDO NETO
DATE: 26/03/2024
TIME: 08:30
LOCAL: CPF - Sede
TITLE:

EPIDEMIOLOGICAL PROFILE AND SPATIAL DISTRIBUTION OF LEPROSY, OCCURRENCE OF PHYSICAL DISABILITIES ASSOCIATED WITH THE EXPRESSION OF THE NEURON-SPECIFIC ENZYME ENOLASE

KEY WORDS:

Leprosy, Georeferencing, Physical disabilities, Neuron-specific enolase

PAGES: 58
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Leprosy is a chronic infectious disease configured as an important current public health problem, endemic inall continents and with greater expression in tropical areas. The Brazil occupies second place in the ranking of countries with the highest absolute number of cases, with greater notification of cases in the Northeast states and the distribution of the disease in the territory is heterogeneous. The municipality of Teixeira de Freitas has an average rate of 32 new cases per year and the general detection rate reveals that this is also an endemic territory, which raises specific considerations from a clinical and epidemiological point of view. In view of this, the present research aimed to identify the epidemiological profile and spatial distribution of leprosy in the municipality of Teixeira de Freitas, and to analyze the relation of neurological damage and physical disabilities resulting from the disease and its relationship with the protein expression neuronspecific enolase (NSE) at the serum and saliva of patients at the end of treatment. The approaches to achieving the objectives were a retrospective epidemiological survey based on secondary data recorded in the medical records available at the Teixeira de Freitas Testing and Counseling Center (CTA); and a crosssectional exploratory study, including 21 patients diagnosed with leprosy treated at the city's CTA from August 2023 to November 2023. In the NSE expression study, patients whose leprosy treatment had been completed more than 1 year ago were included. year and excluded those with neurodegenerative diseases. The abilities to perform motor activities were measured using the QuickDASH questionnaires, consisting of 11 questions, scored on a Likerk scale and whose final score indicates functional deficiency. Saliva and serum samples were collected from patients participating in the research in order to evaluate the activity of markers of neural damage in the disease. The epidemiological survey demonstrated a predominance of cases in male individuals, concentrated in an age group younger than the data demonstrated in studies at state level, there was a greater spectrum of the dimorphic form of the disease and occurrence in 37 of the 69 neighborhoods of the city, predominantly in the East zone. The municipality occupies the 4th position in the order of prevalence of cases in Bahia. It was found that the QuickDASH questionnaire is an accessible and quick diagnostic tool in clinical health care practice, and there is potential to use the Enolase biological marker to identify disability in patients with leprosy resulting from neural damage. The concentration of the disease in areas marked by social inequalities and lack of access to health services highlights the urgency of measures aimed not only at treating already diagnosed cases, but also at prevention and early diagnosis. It is crucial that health policies are adapted to meet the specific needs of the affected population, taking into account issues of gender, access to health services and socioeconomic conditions.

COMMITTEE MEMBERS:
Externo à Instituição - MÁRCIO BEZERRA SANTOS - UFAL
Externa à Instituição - Ana Laura Grossi de Oliveira - UFMG
Interna - 1623806 - GRASIELY FACCIN BORGES
Presidente - 1322722 - SEBASTIAO RODRIGO FERREIRA